Recent Publications


Lin, B.C., Suzawa, M., Blind, R.D., Tobias, S.C., Bulun, S.E., Scanlan, T.S. and H.A. Ingraham, Stimulating the Estrogen Membrane Receptor GPR30 by a Novel Tamoxifen Analog Activates SF-1/LRH-1 Nuclear Receptors and Promotes Endometrial Cell Proliferation. In Revision Cancer Research, 2008.


Sablin, E.P., Krylova, I., Fletterick, R.J. and H.A. Ingraham, Crystal structure of the NR5A nuclear receptor SF-1 bound to a non-bacterial phospholipid, In Revision, Molecular Endocrinology, 2008.


Kurrach, D.M. Nevin, L., Baier, H. and H.A. Ingraham. Maintenance of neuroendocrine transcriptional programs requires synaptic activity as revealed by nsf mutant zebrafish. In Revision 2008.


Campbell, L.A., Faivre, E.D., Show, M.D., Ingraham, J.G., Flinders, J., Gross, J.D. and H.A. Ingraham, Modification of SF- 1 (NR5A1) Results in Decreased Recognition of SUMO-Sensitive Target Genes, In Press, Molecular and Cellular Biology, 2008.

Sablin, E.P., Woods, A., Krylova, I., Ingraham. H.A. and R.J. Fletterick, The structure of the nuclear receptor Dax-1, a major regulator of endocrine function and stem cells, In Press PNAS 2008.


Suzawa, M. and H.A. Ingraham, The widely used herbicide Atrazine activates the endocrine network via non-steroidal NR5A nuclear receptors in fish and mammals, PLoS One PDF (2008) 3(5):e2117. Chosen as Faculty 1000 of Biology Paper (http://www.f1000biology.com/article/id/1108970)


Kurrasch, D.M., Cheung, C., Tran, P.V., Lee, F.Y., Hata, K. and H.A. Ingraham, The neonatal ventromedial hypothalamus transcriptome reveals novel developmental markers with spatially distinct patterning, Journal of Neuroscience PDF 27(50):13624-34 (2007).


Campbell, L. and H.A. Ingraham, Review, Wiley Encyclopedia of Chemical Biology, Chemistry of Nuclear Receptors March, 2008.


Tran, P.V., Akana, S.F., Malkovksa, I., Dallman, M.F., Parada, L.F. and H.A. Ingraham, Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.  Journal of Comparative Neurology PDF 498:637-648 (2006).


Krylova, I.R., Sablin, E.P., Williams, J.D., Williams, S, P., Moore, J., Xu, R.X, Juzumiene, D, Waitt, G.D., Bynum, MacKay, J.M., J.M., Montana, V., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., and H.A. Ingraham,  Structural analyses reveal phosphatidyl inositols (PI) as ligands for the NR5 orphan receptors, SF-1 and LRH-1.  Cell PDF 120: 343-355 (2005). Reviewed in SKTE and in Cell Metabolism.


Ingraham, H.A. and M.R. Redinbo, Orphan Nuclear Receptors adopted by crystallography.  Curr. Opin. Struc. Bio PDF. 6:708-15 (2005).


Lee, M.K., Lebedeva, L., M. Suzawa, M. Desclozeaux, Mi. Suzawa, and Holly A Ingraham. Repression of orphan nuclear receptor activity via SUMO-modification and the Dead-Box Protein DP103 (Ddx20, Gemin-3). In Press, Mol Cell Bio PDF (2004).


Bland, M., Fowkes, R.J. and H.A. Ingraham. Differential requirement for Sf-1 gene dosage in adrenal development versus adult endocrine function. Molecular Endocrinology PDF 4:941-52 (2004).

Fowkes, R., Alwin, S, King, P, Desclozeaux, M, Ingraham, H.A., and J.M. Burrin.  SF-1 and the gonadotrope-specific element (GSE) enhance basal and PACAP-stimulated transcription of the human glycoprotein hormone a-subunit gene in gonadotropes. Molecular Endocrinology 17:2177-88 (2003).

Jordan, B, Shen, J-H, Olaso, R., Ingraham, H.A*. and E.R.Vilain, Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing SF-1/b-catenin synergy. PNAS PDF 100(19):10866-71. Epub 2003 Aug 29(2003). *Corresponding Author

Sablin, E, Krylova, I, Fletterick, R.J. and H.A. Ingraham. Structural basis for ligand-indpendent activation of the orphan nuclear receptor LRH-1. Molecular Cell PDF 11:1575-1585 (2003).
See Reviews "Activation Incarnate" by Martin L. Privalsky in Developmental Cell and "Activation of nuclear receptors: a perspective from structural genomics" by Eric Xu in Structure.

Tran, P. Lee, M., Marin, O., Xu, B. , Reichardt, L.F., Jones, K.R., Rubenstein, J.R. and H.A. Ingraham. Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neuro PDF 22:441-453 (2003).