As a physician-scientist I am well-positioned to study the basic principles underlying human disease. My training in pharmacology and structural biology uniquely shapes my approach to basic scientific questions through an understanding of protein network interactions and emphasizes the importance of clinical translatability. My clinical training in gastroenterology enables my bench-to-bedside focus on intestinal disorders, concentrating on inflammatory bowel disease (IBD) as a model of intestinal disease. My combined clinical and basic science experiences therefore allow me to bring my research directly to the field of pediatric gastroenterology. My long-term research interests include the study of the role of nuclear receptors in intestinal homeostasis and disease response, with a particular interest in drug development and elucidation of key protein signaling interactions. I utilize intestinal organoids, 3D tissue models of intestinal epithelium, coupled with animal models of human disease to probe the molecular underpinnings of gastrointestinal disease. To further research into pediatric IBD, I am developing living biorepository of intestinal organoids derived from our patients. The advantages of the ex vivo intestinal organoid system are significant and have the potential to transform therapeutic management of pediatric and adult IBD while advancing our understanding of the poorly understood mechanisms involved in intestinal self-renewal and wound healing. I apply this technology to the study of Liver Receptor Homolog-1 (LRH-1, NR5A2), a nuclear receptor enriched in intestinal crypts and a potential therapeutic target for IBD. My work has been recognized at international conferences and attracted interest from industry while also growing collaborations at UCSF and beyond.