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Lab News: Ray Blind Starts Position at Vanderbilt  Stephanie Correa Accepts Position at UCLA

 

Central Regulation of Metabolism and Reproduction
We are broadly interested in endocrine and neuroendocrine tissue development. We study the ventromedial hypothalamus (VMH), which controls metablism and reproduction. Using mouse genetics, pharmacogenetics and functional imaging, we ask how estrogen-responsive neurons in the VMH control physical activity and adaptive thermogenesis in females.

Nuclear Lipids and Sumoylation of NR5As
Ongoing research focuses on NR5A nuclear receptors, SF-1 and LRH-1 because of their critical roles in metabolism. We find that the signaling phospholipid PIP3 is the highest affinity ligand for NR5As. Efforts are underway to find synthetic ligands for use in the intestine and liver. NR5A receptors are highly sumoylated. We are asking how this PTM affect the in vivo function of these NRs in liver.


Recent Publications
  • Blind, R.D., Suzawa, M. and H.A. Ingraham, Direct modification and regulation of the nuclear protein-lipid complex NR5A1-PIP2 by the PI3-kinase IPMK. (Cover and Podcast) Science Signaling 2012 Jun 19;5(229) PMID: 22715467 (2012). PDF

  • Cheung, C., Kurrasch, D.M., Liang, J. and H.A. Ingraham, Genetic Labeling Of SF-1 Neurons Reveals VMH Circuitry Beginning At Neurogenesis And The Emergence Of A Separate Non-SF-1 Neuronal Cluster In The Ventrolateral VMH J Comp Neurol 2013 Apr 15;521(6):1268-88, PMID: 22987798. PDF

  • Correa, SM, Newstrom, DW., Warne,JP., Flandin, P., Cheung, CC., Lin-Moore, AT., Pierce, AA., Xu, AW, Rubenstein, JL. and H.A. Ingraham. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Reports 2015 Jan 6;10(1):62-74. PMID: 25543145. PDF

  • Blind, R.D., Sablin, E.P, Kuchenbecker, K., Chui, H-J. Deacon, A., Das, D., Fletterick, R.J. and H.A. Ingraham, The Signaling Phospholipid PIP3 Binds SF-1 Creating A New Interaction Surface at the Entrance of the Ligand Binding Pocket, Proc Nat Acad Sci Oct 21;111(42):15054-9 (2014) PMID: 25288771. PDF
         Featured in May 2015 Website PSI - Nat. Structural Biology


Holly Ingraham, Ph.D.

Professor and Associate Vice Chair, Cellular and Molecular Pharmacology, Herzstein Distinguished Investigator
1550 4th Street, Rock Hall 284E San Francisco, CA 94143
Lab Phone: 415-476-3401, Office Phone: 415-476-2731
holly.ingraham@ucsf.edu

 


  
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