News

Muriel Receives Outstanding Abstract Award from Endocrine Society

Adult Endocrine Fellow, Dr. Muriel Babey receives the Outstanding Abstract Award for the 2022 Endocrine Society Meeting. 

Read Archana's BioRxiv Preprint on Gut Pain and Anxiety

The latest group effort between the Julius/Ingraham/Bayrer/Brierley Labs highlights the importance of EC cells in gut visceral pain and anxiety. Link to Paper and Figures 

Joni Receives Prestigious K99 from NIDDK

I will be exploring sex differences in host immunity for the next few years! Thanks to everyone who helped me on the pathway to independence.

@hollyingrahamSF

@DrEmilyGoldberg

@SuneilKoliwad

 and Jackie Maher.

 

Follow me on twitter: https://twitter.com/joni_nikkanen

Read Joni's BioRxiv Preprint on Trade-offs in Sex Biased Diseases

ABSTRACT

Current concepts in evolutionary medicine propose that trade-offs and mismatches with a shifting environment increase disease risk. While biological sex also impacts disease prevalence, contributions of environmental pressures to sex-biased diseases remain unexplored. Here, we show that sex-dependent hepatic programs confer a robust (~300%) survival advantage for male mice during lethal bacterial infection. The transcription factor BCL6, which masculinizes hepatic gene expression at puberty, is essential for this advantage. However, protection by BCL6 comes at a cost following dietary excess, resulting in overt fatty liver and glucose intolerance in males. Deleting hepatic BCL6 reverses these phenotypes but markedly lowers male fitness during infection, thus establishing a sex-dependent tradeoff between host defense and metabolic systems. We suggest that these tradeoffs, coupled with current environmental pressures, drive metabolic disease in males.

Link to Full Text and Figures

Archana Receives Microbiome Research Pilot 2021 Award

 

Archana receives new funding to pursue the role of estrogen signaling in the gut and its effect on the microbiome from the Benioff Center for Microbiome Medicine - See All of the 2021 Awardees. Their Mission: The microbiome research community at UCSF is focused on some of the biggest chronic disease issues of our time with an emphasis on translating discovery into innovative treatment solutions. The human body is home to a thriving community of diverse microbes whose activities and products shape our health. Our mission is to accelerate our understanding of how microbes promote health and prevent disease and to leverage this information to develop novel, effective treatment paradigms bringing them to patients in the shortest possible time.

 

 

Adriana Receives Longevity Impetus Award

 

Ms. Padilla, a Neuroscience Graduate Student, receives a newly announced "fast grant" to study the role of drugs in motivating activity in a mouse model. Reasoning that exercise is recognized as one deterrent of dementia and cognitive failure during aging, Adriana wishes to know if triggering a neurocircuit for promoting spontaneous activity, describes in Krause et al., 2021 reverses aging in mice. This new grant mechanism provides funding for scientists to start working on what they consider the most important problems in aging biology, without delay. For more information on this unique funding mechanism, please go to this link to learn more.

Krause et al., in the New York Times

Congrats to Bill and the rest of the team.

Their work was recently covered by Gretchen Reynolds in the NYT Science Times on 10/26/21. 

Joni Receives PBBR Postdoctoral Independent Research Award

Independent Postdoctoral Fellow Research Award

$15,000 one-year fellowship for meetings, courses, or research expenses

These fellowships are designed to encourage creative and independent research driven by postdoctoral scholars. The fellowships support UCSF postdocs who wish to explore biomedical research directions that are not directly linked to the research interests of their postdoctoral mentor and require the engagement of an additional collaborator or co-mentor. The Call for Proposals for the Independent Postdoctoral Fellow Research Award is announced once a year. Joni has been looking at evolutionary tradeoffs as a way to explain our current sex-biased diseases, specifically at the interface between host defense responses and metabolism in the liver. 

Muriel Receives Weill Award for Junior Investigators in Neurosciences

 

Drs. Lin Yuan (Julius Lab) and Muriel Babey (Ingraham Lab) were awarded a Weill Award for Junior Investigators in the Neurosciences Impacted by COVID-19 Setbacks in the amount of $50,000

Combining their basic and clinical expertise, this team of junior scientists will begin probing a new model to better understand diabetic neuropathy.

Project Title: Mechanisms of sensory nerve damage in type 2 diabetes – a role for insulin dysregulation?

 

Adriana Padilla Roger Receives NSF Fellowship

Adriana Padilla was one of four UCSF neuroscience graduate students to be awarded an NSF in 2021. A huge achievement! We can't wait to see what you do in the next 3-4 years.