Our Research

Photo Credit: Dr. William Krause

 

Sex-Dependent Central Regulation of Female Metabolism and Physiology

We are broadly interested in how the female brain uniquely controls a wide-range of sex-specific physiological responses. Currently, we focus on estrogen signaling in the medial basal hypothalamus (MBH) that includes the ventromedial hypothalamus (VMH) and the arcuate nucleus (ARC). Mouse models coupled with genomics and pharmacogenetics are leveraged to define the estrogen-sensitive neuronal modules important in locomotion, thermogenesis, reproduction and bone density. Our research program is highly relevant to age-related diseases in hormone deficient stages and to women’s health. 

 

Photo Credit: Dr. James Bayrer

 

Understanding Intestinal Epithelial Biology

The intestinal epithelium comprises the human body’s greatest environmentally exposed surface and represents the largest sensory and endocrine organ. We utilize intestinal organoids and animal models to understand how the intestine senses and responds to regular and inflammatory stimuli. By investigating the molecular pathways involved, we aim to discover new ways to promote intestinal wound healing and modulate the signals contributing to visceral pain syndromes.

 

Consider donating to the Ingraham Lab to continue researching to reverse osteoperosis

 
 
 
 
 
 
 

Recent Publications

Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones
Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham, HA. Nature Commun. Jan 2019.
Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. Nat Commun. 2018 Oct 10.
Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierly SM, Ingraham HA, Julius DJ. Cell. June 2017